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KMID : 0378019840270120136
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New Medical Journal
1984 Volume.27 No. 12 p.136 ~ p.140
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A Clinical Trial on Clebopride Malate(Cleborile^(®)) in Irritable Bowel Syndrome in Korea
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Abstract
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The efficacy of Clebopride malate(Cleboril®) was evaluated in 72 patients with irritable bowel syndrome. Clebopride malate was administered at dose of 0.5mg tid orally at least for four weeks. The result was as follow;
1. Nausea and vomiting, which were experienced by every patients with some variation in severity were completely relieved in 86% and 76% after four weeks of treatment.
2. Abdominal bloating and early satiety were also completely relieved in 85% and 86% of patients after four weeks of treatment respectively.
3. Abdominal pain and changing bowel habits were relieved in 79% and 84% with this regimen.
4. Comprehensive effectiveness of subjective symptoms were excellent in 80 %( 49/61) of treated group respectively.
5. As the untoward side effect of Clebopride malate, drowsiness was noticed in about 2% of treated group. However this symptom was never serious enough to discontinue medication, otherwise there was no physical or laboratory abnormalities observed during or after treatment with this drug so far.
The authors concluded Clebopride malate(Cleboril®) appears to be effective and safe for the treatment of patients with irritable bowel syndrome.
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